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Regulon contains 30 μg of ethinylestradiol and 150 μg of desogestrel, as well as ancillary components: magnesium stearate, α-tocopherol (Alfa-tocopheryl acetate), silicon dioxide colloid (Silicon dioxide colloidal), stearic acid (Stearic acid) povidone (Povidone), potato starch (Solani amylum), lactose monohydrate (Lactose monohydrate).The film membrane is manufactured using Macrogol 6000 macrogol, Propylene glycol, Hypromellose.
Regulon enters the pharmacy in the form of film-coated tablets. Tablets are packaged in 21 pieces in blisters, 1 or 3 blisters in one carton.
The drug belongs to the group of combined monophasic oral contraceptives. Pharmacological action Regulon - contraceptive, estrogen-progestagen.
According to the annotation, the mechanism of action of the drug is based on the ability of its active substances to suppress the synthesis of gonadotropins by the pituitary (in particular, luteinizing and follicle-stimulating hormones).This makes it difficult to ovulate, increases the density of cervical mucus and, as a consequence, prevents the penetration of spermatozoa into the internal space of the uterus.Ethinyl estradiol is a synthetic analogue of estradiol, which begins to be produced in the body of a woman, beginning with the first menstruation.Desogestrel has a pronounced gestagenic and anti-estrogenic effect similar to that of endogenous progesterone. The substance is characterized by weak anabolic and androgenic activity.During the reception of Regulin tablets, women (in the case of initial menorrhagia) significantly reduce blood loss during menstruation and improve the condition of the skin (especially if there are vulgar acne).Both desogestrel and ethinyl estradiol are quickly and practically completely absorbed from the digestive tract. Desogestrel is immediately metabolized to form a biologically active metabolite - 3-keto-desogestrel.Plasma concentration reaches its maximum:
after 1.5 hours - for desogestrel (plasma concentration index - 2 ng in 1 ml)    after 1-2 hours - for ethinyl estradiol (plasma concentration index - 80 pg in 1 ml).Bioavailability index:
for desogestrel - from 62 to 81%    for ethinyl estradiol - about 60% (this is due to the presystemic conjugation and the effect of the first passage of the substance through the hepatic barrier).Half-life:
for 3-keto-desogestrel - 30 hours (metabolic products are excreted in urine and intestinal contents in the proportion of 4: 6)    for ethinyl estradiol - 24% (approximately 40% of the substance and its metabolites are excreted in the urine, the remaining approximately 60% - with the contents of the intestine).
The annotation to Regulon indicates that the main purpose of the drug is to prevent unwanted pregnancy.However, studies confirm that in addition to the contraceptive effect, Regulon is also characterized by the presence of a therapeutic effect. So, the question "tablets - from what they?" The instruction to the drug answers that the use of Regulon is appropriate for dysfunctional uterine bleeding, premenstrual syndrome, dysmenorrhea, etc ..The drug effectively removes periodically aching aching pain in the lower abdomen, contributes to the reduction of soreness and abundance of menstrual bleeding, dyspravia, eliminates minor secretions of dark color from the genital tract in the perimenstrual period, as well as the soreness of the mammary glands.It is often prescribed to improve the effectiveness of the therapy prescribed for endometriosis. In case of uterine myoma, the agent is prescribed to stop the growth of the tumor (this is advisable if the diameter of the latter does not exceed 2 cm). In addition, Regulon promotes resorption of retention cysts of the ovaries.After 40 years, when a woman, as a rule, has already solved the issues of family planning and the birth of the required number of children, Regulon helps prevent abortion and its adverse consequences (if statistics are to be believed, most of the pregnancies at this age result in artificial abortion).
Contraindications to the application of Regulon are:    intolerance to any component of the drug    pregnancy    lactation    serious liver disease    functional (benign) hyperbilirubinemia (including rare hereditary pigmentary hepatoses)    indicated in the history of jaundice of pregnant women    family forms of hyperlipidemia    indicated in a history of liver tumors    moderately severe or severe arterial hypertension    the history of thrombosis or thromboembolism, the presence of clearly expressed and / or multiple risk factors for their development, as well as the presence in the anamnesis of information that the woman had precursors of thrombosis    migraine    herpes of type II    vaginal bleeding of an unclear origin    detected or suspected estrogen-dependent tumors    severe forms of diabetes mellitus (with angiopathy)    diabetes of pregnant women    disturbed hemocoagulation system    severe itching, otosposgios (or their progression) associated with a previous pregnancy or taking glucocorticosteroids.
The most dangerous side effects of Regulon, which require the withdrawal of the drug, include:    arterial hypertension    thromboembolism of veins and arteries (including the formation of thrombi in deep veins, stroke, myocardial infarction, etc.)    thromboembolism of veins and arteries of the liver and kidneys, as well as thromboembolism of the retial and / or mesenteric veins and arteries (very rarely)    provoked by otpongiozom loss of hearing    porphyrin disease    hemolytic-uremic syndrome    exacerbation of the course of reactive systemic lupus erythematosus (in rare cases)    the rheumatic chorea that disappears after the remedy is abolished (in extremely rare cases).The group of less serious side effects of the drug include:
not associated with menstruation acyclic bleeding, as well as the appearance of bloody vaginal discharge    marked after the withdrawal of the amenorrhea    changes in the state of cervical (vaginal) mucus    increase, tension and tenderness of the mammary glands    the occurrence of inflammatory processes in the vagina    thrush    galactorrhea    nausea    vomiting    development or exacerbation of the associated itch and / or jaundice    Crohns disease (granulomatous enteritis)    cholelithiasis    nodosum or exudative erythema    the appearance of rashes on the skin    Chloasma    headache    changeability of mood    migraine    depression    increased sensitivity of the cornea of the eye    a decrease in tolerance (tolerance) to carbohydrates    weight gain    accumulation of fluid in the body    allergic reactions.
Tablets start to drink from the 1st day of the menstrual cycle, one per day, at the same time of day, for 3 weeks (21 days). After the last tablet is dosed, it is necessary to withstand a seven-day interval during which bleeding similar to the menstrual period should pass.On the 8th day after the last tablet was dosed (4 weeks after the start of the drug, on the same day of the week), even if the bleeding did not stop, taking the pills is resumed from the next blister.How long can I take Regulon?
According to the above-described scheme, tablets are taken as long as the need for contraception remains. If a woman drinks tablets, following all the rules and recommendations specified in the Regulon instructions, the contraceptive effect is also maintained during the seven-day interval.The first pill
The first tablet of the drug is drunk on the 1st day of the cycle. However, there is no need to use additional methods of contraception. If the reception is started between 2 and 5 days of the cycle, then during the first 7 days of the first cycle of Regulon, barrier contraceptives should be used.If after the onset of menstrual bleeding more than 5 days have passed, it is advisable to start taking the drug in the next cycle.How to drink Regulon after childbirth?
In case a woman does not breast-feed, after 21 days after delivery, she can start taking pills (after preliminary consultation with her gynecologist). In such a situation, there is no need to use additional contraceptives.If, after childbirth, there was sexual contact, then the beginning of Regulon intake is recommended to be postponed until the next cycle.If the drug is taken more than 3 weeks after the delivery, additional methods of contraception should be used in the first 7 days of the first cycle of admission.Receiving tablets after an abortion
If there are no contraindications, the pill is allowed to drink already from 1 day after the abortion, and not supplementing them with other contraceptives.Also Regulon is often prescribed after scraping.The expediency of prescribing pills after abortion / curettage (in particular after a stiff pregnancy) is caused by the need to restore normal ovarian function and prevent the development of inflammatory complications, which are reported by statistics in about one in three women who have had a second abortion.The optimal means are drugs, which include a highly active gestagenic substance that does not have side effects, and in particular, Gedeon Richter tablets Regulon.The drug intake can compensate for the progesterone deficiency caused by abortion and the development of proliferative processes associated with it in the reproductive system (including hypertrophy of the tissues, polycystic ovaries, adenomyosis, fibromyoma, endometrial hyperplasia, endometriosis, hypertecosis, mastopathy, etc.).
When switching to a drug from another contraceptive, the first tablet should be drunk the day after the end of the 28-day package (21 days of intake + 7 days off). There is no need to use additional contraceptives.When going to Regulon with mini-pills, the first pill is taken on the 1st day of the cycle, not supplementing the reception using other methods of contraception.If there is no menstrual bleeding during the minipillary period, Regulon can be started on any day of the cycle, but only after pregnancy is excluded.In the first 7 days of the first cycle of admission, there is a need for additional measures of prevention, for which a condom, a cap with spermicidal gel is usually used, or they refrain from having sexual intercourse. The calendar method of contraception in this case is ineffective.
When it is necessary to delay menstruation, the tablets continue to be taken without a break in 7 days. When delaying menstrual bleeding, breakthrough bleeding or spotting can occur, which, however, does not reduce the contraceptive effect of the drug.Regular intake of tablets is restored after a 7-day interval.How do I take Regulon when I miss a pill?
If, after missing the tablet, no more than 12 hours pass, the forgotten pill is taken immediately after it has been remembered. Further reception continues about the familiar pattern.If the interval between doses is more than 12 hours, the reliability of the drug in this cycle can not be considered 100%. Therefore, additional contraceptives should be used before the next cycle.If you skip 1 tablet in the first 7-14 days of the cycle, you should take 2 tablets immediately the next day, after which the reception is continued in the usual way with the use of additional contraceptives until the end of the cycle.If the tablet was missed between 14 and 21 in the afternoon, the regular reception continues, taking a forgotten pill and not taking a 7-day break.If you miss a dose, the risk of ovulation and / or the appearance of bloody vaginal discharge increases. This is due to the fact that the composition of the drug includes a minimal dose of estrogen, and requires the use of additional contraceptives.
Symptoms of an overdose of Regulon are:    dyspepsia    nausea    vomiting    severe headache    cramps of the calf muscles    not associated with menstrual bleeding from the vagina.Since the agent does not have a specific antidote, symptomatic therapy is prescribed for relief of overdose symptoms. The first aid after taking a high dose of Regulon is a gastric lavage (it is recommended to do it in the first two to three hours after taking the tablets).
The effectiveness of oral contraceptives is reduced in combination with drugs that induce liver enzymes: rifampicin, hydantoin, carbamazepine, barbiturates, oxcarbazepine, felbamate, primidon, topiramate, St. John's wort preparations, griseo-wolfin.In addition, used in combination with Regulon, these drugs increase the likelihood of breakthrough bleeding.The level of induction reaches a maximum not earlier than 2-3 weeks later, however it can persist up to 4 weeks after drug withdrawal.Violation of the menstrual cycle and a decrease in the contraceptive effect can be noted with simultaneous application with:    antibiotics (in particular with Tetracycline and Ampicillin)    barbiturates    some antispasmodics    laxatives    antidepressants.In the case when the above mentioned drugs are needed, it is recommended to be protected with barrier contraceptives (during the entire treatment period, and also for an additional 7-28 days, depending on what medicine was prescribed).If it is necessary to use anticoagulants during the regulon intake, additional prothrombin time monitoring should be performed. In some situations, correction of the anticoagulant dosage regimen may be required.Because of the increased likelihood of complications, Regulon should not be combined with hepatotoxic agents.Against the background of taking oral contraceptives can:    decrease tolerance to carbohydrates    increase the need for oral antidiabetic drugs and insulin.Storage conditions
The optimum temperature regime for Regulon storage is from 15 to 30 degrees Celsius. Keep away from children.Shelf life - 36 months.
If Regulon's administration is accompanied by a worsening of liver function tests, it is recommended that you stop taking the pills immediately.In the first few months of taking the drug, acyclic intermenstrual bleeding may occur, which are not grounds for the abolition of tablets. Nevertheless, if they continue for three months or more, a detailed examination is necessary.Since women taking Regulon are accompanied by an increased risk of thromboembolic complications, they are advised to decide on quitting smoking.If the monthly after Regulon does not occur in the second cycle, the probability of pregnancy should be excluded.Teratogenic action of Regulon has not been proven. For this reason, if there is a pregnancy with the taking of tablets, there is no need for interruption.How long can I take Regulon?
During the reception of Regulon tablets, changes occur in the woman's body, characteristic of the first weeks of pregnancy. Women who already have children in the reproductive system have the same processes that would occur if she gave birth and nurtured several children.It is well known that the birth of a large number of children is the most effective method of protecting against cancer of the organs of the reproductive system and mammary glands.Thus, the long reception of Regulon enhances the therapeutic effect of the drug. Taking pills is allowed until the woman is faced with the issue of planning a child.
As a rule, menstrual bleeding when taking Regulon becomes more scarce. However, it also happens that a woman can become addicted to the drug, which often manifests itself in the form of smearing excretions.The discontinuation of taking tablets is usually accompanied by increased ovarian function. Therefore, one of the consequences of the abolition of Regulon can be very abundant menstrual bleeding.If there is no period after cancellation, this may also be due to a failure in the function of the ovaries. As a rule, it and, hence, the menstrual cycle, are restored a month after the termination of Regulon's administration. To determine the level of hormones in the body, gynecologists are advised to take the necessary tests after a month after the drug was discontinued.Regulon and weight: do they get fat from hormone tablets?It is generally believed that taking hormonal contraceptives can provoke an increase in body weight. However, the doctors claim that, with all the rules of Regulon intake, as well as the regime of the day and nutrition, the tablets do not have any effect on the weight of the woman.Usually weight gain on the background of taking birth control pills may be due to the fact that the desogestrel included in their composition is characterized by the ability to retain fluid in the body (so, it is progesterone that causes swelling during pregnancy).The hormones in the Regulon help accelerate the biochemical reactions of lipids and carbohydrates. If the level of physical activity is estimated as sufficient, excess calories can easily be converted into energy, but with insufficient loads they settle on the body in the form of extra pounds.
With the proper administration of Regulon, the probability of pregnancy is negligible. The effectiveness of the drug is very close to 100%.The risk of becoming pregnant is highest during the period of contraceptive replacement, in cases when there were missing tablets, disturbances in the regimen (tablets were taken every time at different times) and also if the effect of the tablet was neutralized (for example, by an absorbent).
Similar preparations in composition (synonyms) are Merсilon, Novinet.In case the woman is interested in what can replace the product, the doctor can advise her one of the following drugs: Yaz, Jeanine, Yarina.What is better - Regulon or Novinet?
Regulon and Novinet are generic drugs. They have the same composition, indications for use and contraindications, but are issued by different companies.Regulon or Jeanine - which is better?
Both Regulon and Janine are low-dose monophasic contraceptives. They have a similar mechanism of action, but they differ in composition. Regulon is a combination of ethinyl estradiol and desogestrel, and in the formulation of Jeanine ethinylestradiol is supplemented with dienogest (the dose of the progestogen component in the Janine pellet is slightly higher than in Regulon).The most significant difference in drugs is their price - Regulon is much cheaper than its counterpart.
Alcohol does not affect the pharmacological profile of the drug, but in a number of diseases it can provoke a worsening of their course: for example, with epilepsy, alcohol in combination with Regulon can cause seizures.
Pregnancy is an absolute contraindication to the appointment of Regulon. During lactation, you should stop taking the medication or stop breastfeeding.This is due to the fact that taking pills in the postpartum period provokes a decrease in the amount of milk, worsens lactation and adversely affects the growth of the baby.
The contraceptive effect of Regulon tablets is related to the ability of its synthetic analogues of endogenous hormones, estradiol and progestogens, to prevent the emergence of a mature egg from the follicle.As a contraceptive, the drug is allowed to be used for several years. However, many women are concerned about whether this will somehow affect the reproductive function and subsequently on pregnancy.Gynecologists respond to similar questions like this: if you take the pills correctly (that is, take the scheme described in the instructions, and with all the recommendations of your doctor), then upon completion of their admission you can plan pregnancy. Usually the pregnancy after Regulon comes about after 6 months of active sexual activity.A woman who plans a child, doctors recommend stopping the drug at least three months before conception.
Contraceptive pills Regulon - reviews are a confirmation of this - this is one of the most popular means of contraception.Most women who take them are aware of the small number of side effects of the drug, its reliability, affordable price, and the fact that pregnancy after the abolition of tablets occurs without any problems (in forums those who become pregnant after Regulon leave a considerable amount of positive feedback about this drug).Nevertheless, there are also negative reviews of Regulon's side effects. As a rule, they are associated with the appearance of acyclic bleeding of varying degrees of intensity, itching in intimate zones, nausea, and a set of excess weight.Referring to the doctors' reviews about Regulon, one can come to the conclusion that such phenomena are most often caused by intolerance to any component of tablets or because the drug is simply not suitable for a particular organism. To minimize side effects, it is recommended that you follow the instructions for the use of tablets.If, however, in this case there is no improvement, it is necessary to decide whether to cancel the drug, undergo the necessary examinations and select another contraceptive.'
|The purpose of the medication||Contraception|