Milgamma compositum tabs 100mg #30

Milgamma compositum instruction

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See also - Milgamma

Composition

The composition of the drug Milgamma Compositum includes the active substances benfotiamin and pyridoxine hydrochloride. Also in the composition of tablets are additional substances: povidone K, microcrystalline cellulose, carmellose sodium, silicon dioxide colloid, incomplete glycerides of higher fatty acids, talc.

Form of issue

The preparation is available in the form of a white biconvex round pellet. In the contiguous cells, 15 tablets are packed, 2 or 4 packs are put in cardboard boxes.

pharmachologic effect

Milgamma Compositum tablets are a complex of B vitamins. Active ingredients of the drug - benfotiamine and pyridoxine hydrochloride - facilitate the patients condition in inflammatory and degenerative diseases of the nerves, as well as the motor apparatus. Milgamma in tablets activates the blood flow, contributes to the improvement of the functions of the nervous system.Benzothiamine is a substance that plays an important role in the metabolism of carbohydrates. Pyridoxine participates in the body in the metabolism of protein, it is partly involved in the metabolism of fats and carbohydrates. Benfotiamin and pyridoxine in high doses act as an anesthetic due to the participation of benfotiamine in the synthesis of serotonin. There is also a regenerating effect: under the action of the drug, the myelin sheath of the nerves is restored.

Pharmacokinetics and pharmacodynamics

Benzothiamine is a fat-soluble vitamin B1 derivative (thiamine). In the body, this substance is phosphorylated into thiamine diphosphate and thiamine triphosphate, which are biologically active coenzymes. The main part of benfotiamine is absorbed in the duodenum, the rest of it is in the small intestine.Pyridoxine is processed into pyridoxal phosphate. This enzyme affects the non-oxidative metabolism of amino acids. It takes part in the production of physiologically active amines. It is mainly absorbed in the upper parts of the digestive tract during passive diffusion.Both active substances are excreted mainly through the kidneys. The half-life of benfotiamine from the blood is 3.6 hours, the half-life of pyridoxine is 2-5 hours.

Indications for use

The following indications for the use of Milgamma Compositum in the complex treatment are defined:    neuritis    retrobulbar neuritis    neuralgia    ganglionitis    paresis of the facial nerve    plexopathy    polyneuropathy, neuropathy    lumboishalgia    radiculopathy.Also, there are indications for the use of this drug in people who regularly suffer from nocturnal cramps (primarily elderly people) and muscular-tonic syndromes. What else is prescribed the drug, the doctor determines individually.

Contraindications

Medication Milgamma Compositum can not be used for such diseases and conditions of the body:    chronic form of heart failure (decompensation stage)    intolerance to fructose of a hereditary nature    insufficiency of sugar or isomaltase    impaired absorption of galactose or glucose    high sensitivity to the components of the drug.

Side effects

Milgamma Compositum tablets, like Milgamma injections, can provoke some side effects, which, as a rule, only appear in rare cases. The following manifestations are possible:    urticaria, itching of the skin, shortness of breath, Quinckes edema, anaphylactic shock    tachycardia    reactions associated with high sensitivity    severe sweating, acne    headache    nausea.If any of these side effects are expressed, tell the doctor immediately.

Instructions for use Milgamma Composite (Method and dosage)

When ingesting dragees, you should drink plenty of fluids.If the patient is prescribed Milgamma tablets, the instructions for use include taking 1 tablet a day. In acute cases, the dose may increase: 1 tablet a day three times a day. In this dosage, treatment can be carried out for no more than 4 weeks, after which the doctor decides to reduce the dose, as when taking vitamin B6 in large quantities increases the likelihood of developing neuropathy. In general, the course of therapy lasts no more than two months.

Overdose

In case of an overdose of vitamin B6, neurotoxic effects may occur. When treating large doses of this vitamin for more than six months, the development of neuropathy is possible. In case of an overdose, sensory polyneuropathy may occur, which is accompanied by ataxia. Taking large doses of medication can trigger the appearance of convulsions. An overdose of benfotiamine when taken orally is unlikely.After taking high doses of pyridoxine, you should induce vomiting, after which take activated charcoal. However, such measures are effective only in the first 30 minutes. In more serious cases, you should immediately contact a specialist.

Interaction

In the treatment of drugs that contain vitamin B6, the effectiveness of levodopa may decrease.At simultaneous treatment with pyridoxine antagonists or with prolonged intake of oral contraceptives containing estrogens, vitamin B6 deficiency may be noted.With simultaneous reception with fluorouracil, thiamine is deactivated.

Terms of sale

In the pharmacy, Milgamma Compositum is sold without a prescription.

Storage conditions

Keep dragees at a temperature not exceeding 25 ° C, protect from children.Shelf life - 5 years.

special instructions

Taking medication does not affect the level of concentration when driving vehicles and working with dangerous mechanisms.

Children

The drug is not assigned to children due to the lack of clear information about the safety of the drug.

In pregnancy and lactation

During pregnancy and during breastfeeding, Milgamma Compositum is not prescribed.

Reviews about Milgamma Compositum

Reviews about Milgamma Compositum on the forums in most positive. It is noted that the drug helps to get rid of unpleasant symptoms, obsessive neurologic pains, seizures. Reviews of tablets rarely contain information about the manifestation of side effects.