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The composition and form of issue:
Lyophilisate for preparation of solution for intramuscular injection. 1 vial contains:
human menopausal gonadotropin in an amount corresponding to 75 IU FSH and 75 IU LH
complete with solvent in 1 ml ampoules in a cardboard box in 5 or 10 sets.
Contains FSH and LH in a 1:1 ratio. In women it stimulates the growth and maturation of follicles in the ovaries and endometrial proliferation, increases the level of oestrogen in men it stimulates spermatogenesis.
In women: infertility, due to hypothalamic-pituitary disorders, conduct of assisted reproductive technologies for the onset of conception.
Men: azoospermia and oligoasthenospermia due to primary or secondary hypogonadotropic hypogonadism (in combination with the drug human chorionic gonadotropin — hCG).
Hypersensitivity. For women: persistent increase in the occurrence of ovarian or ovarian cysts not due to polycystic ovary syndrome, developmental abnormalities of the genital organs, myoma of the uterus incompatible with pregnancy vaginal bleeding of unknown etiology, ovarian carcinoma, uterine or breast primary ovarian failure pregnancy lactation.
For men: prostate cancer or other androgen-dependent tumors.
From the digestive tract: nausea, vomiting.
From the urogenital system: moderate (uncomplicated) increase in ovarian formation of ovarian cysts, ovarian hyperstimulation syndrome (severe pain in the abdomen, nausea, vomiting, increase in body weight, hypovolemia, an increase in the number of red blood cells in plasma is associated with reduced plasma volume, electrolyte imbalance, ascites, hemoperitoneum, hydrothorax, thromboembolic syndrome).
Allergic reactions: fever, skin rash.
Other: antibody formation, at the injection site — pain, redness, swelling or itching.
Method of application and dose:
V/m or n/a.
Infertility in women, due to hypothalamic-pituitary disorders: usually begin with a dose of 75-150 IU (1-2 ampoules) a day, in the absence of ovarian response dose gradually increasing to register increase in estrogen blood or follicular and save before reaching the preovulatory estrogen levels. For ovulation induction in 1-2 days after the last injection administered once 5000-10000 IU.
In men to stimulate spermatogenesis — pre-injected with 1000-3000 IU of human chorionic gonadotropin (hCG) 3 times a week after normalization of testosterone levels in the blood injected Menopur on 75-150 IU (1-2 mg) 3 times a week for several months.
The dose for stimulation of growth of one dominant follicle is chosen individually and depends on the reaction of the ovaries. The optimal dose and duration of treatment set on the basis of ultrasound of the ovaries, levels of estrogen in the blood and clinical observation. On follicular maturation is judged to increase the level of estrogen in your blood.