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Structure and Composition:
One tablet contains dexketoprofen trometamol 36.9 mg
(Corresponding to 25 mg of dexketoprofen)
Excipients: MCC cornstarch glyceryl sodium carboxymethyl
shell: hypromellose macrogol 6000 titanium propylene dvuoksid
in blister 10 pcs. a stack of cardboard 1, 3 or 5 blisters.
Description pharmaceutical form:
Round, white biconvex film-coated tablets, scored for dividing both sides.
Trometamolovaya salt of propionic acid NSAIDs belonging to the group.
Reduce GHG due to suppression of the synthesis of cyclooxygenase system.
After oral administration, Cmax is reached at 30 (15-60) minutes. distribution of time – 0.35 h, T1 / 2 -. 1.65 hours mean volume of distribution – less than 0.25 l / kg. Binding to plasma proteins – 99%. Write mainly by the kidneys after glyukuronirovaniya.
Description of the pharmacological actions:
Analgesic action occurs within 30 minutes after administration and lasts 4-6 hours.
Pain of mild and moderate intensity of acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondylitis, osteoarthritis, low back pain), menstrual pain and toothache.
Hypersensitivity (including to other NSAIDs), gastric ulcer and duodenal ulcer disease, gastrointestinal bleeding or other active bleeding, bleeding tendency, anticoagulant therapy, gastro-intestinal diseases (Crohn’s disease, ulcerative colitis), bronchial asthma (including history), severe heart failure, renal and / or hepatic insufficiency, pregnancy, breastfeeding.
Application of pregnancy and breastfeeding:
Contraindicated during pregnancy. At the time of treatment should stop breastfeeding.
From the digestive tract: indigestion, abdominal pain, rarely – erosive and ulcerative gastrointestinal damage.
From the nervous system and sensory organs: headache, dizziness, nervousness, insomnia, paresthesia.
Cardio-vascular system and blood (blood, hemostasis): palpitations, increased blood pressure, rarely – a violation of the blood picture.
Allergic reactions: skin rash, bronchospasm.
From the urogenital system: rarely – renal dysfunction.
Other: fever, swelling of extremities, photosensitivity.
Dosage and administration:
Inside, the recommended dose (depending on the type and intensity of pain) – Table 1/2. 1-6 times a day with an interval between doses – 4-6 hours or 1 table. 1-3 times a day at intervals between doses – 8 hours for 3-5 days (maximum). The maximum dose – 75 mg / day, the elderly, patients with impaired liver or kidney function – no more than 2 tablets. per day.
Treatment: gastric lavage, symptomatic therapy.
Be wary appoint elderly, children, allergies, systemic connective tissue diseases and disorders of hematopoiesis. In severe kidney disease should not use the drug. Not recommended for use during the drivers of vehicles and people skills relate to the high concentration of attention. C caution is used in conjunction with other analgesic and anti-inflammatory drugs, drugs that reduce blood clotting, drugs lithium, methotrexate, phenytoin and sulfonamides.
|The purpose of the medication||Derivatives of propionic acid|