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INN: Pyridoxine + Cyanocobalamin + Thiamine + [Lidocaine].The composition of 1 ml of this solution of Combilipen includes the following active substances: thiamine hydrochloride - 50 mg, pyridoxine hydrochloride-50 mg, cyanocobalamin-500 μg, lidocaine hydrochloride - 10 mg. As adjuvants: benzyl alcohol, sodium hydroxide, potassium hexacyanoferrate, sodium tripolyphosphate, water for injection.The composition of 1 tablet of the drug is: pyridoxine hydrochloride - 100 mg, benfotiamine - 100 mg, cyanocobalamin - 2 μg. As auxiliary substances: carmellose sodium, microcrystalline cellulose, povidone K30, calcium stearate, talc, polysorbate, sucrose.
The drug is released as a solution for injections and tablets. The drug in the form of a solution is contained in ampoules of 2 ml, the package includes 5, 10 and 30 ampoules. Tablets Combilipen Tubs round, covered with a film white shell, biconvex. They are sold in cell packs of 15, 30, 45 or 60 pieces in cardboard boxes.
The drug is a multivitamin complex, which includes several components.Thiamine hydrochloride (vitamin B1) provides nourishment for the nerve cells of the body with glucose. Lack of glucose leads to deformation and a subsequent increase in nerve cells, which ultimately provokes a violation of their immediate functions.Pyridoxine hydrochloride (vitamin B6) takes a direct part in the metabolic processes of the central nervous system. It provides normalization of nerve impulses, excitation and inhibition, and also takes part in the synthesis of catecholamines (epinephrine, norepinephrine) and in the transport of sphingosine (a component of the nervous membrane).Cyanocobalamin (vitamin B12) participates in the production of choline, the main substrate for the synthesis of acetylcholine (acetylcholine is a neurotransmitter that takes part in conducting nerve impulses), hemopoiesis (promotes the maturation of red blood cells and ensures their resistance to hemolysis). Also, cyanocobalamin is involved in the synthesis of nucleic acids, folic acid, myelin. It increases the ability of body tissues to regenerate.Pharmacodynamics and pharmacokinetics
Information on pharmacokinetics and pharmacodynamics is not provided.
Indications for the use of this drug are a number of neurological diseases:    neuralgia of the trigeminal nerve    inflammation of the facial nerve    polyneuropathy, which has a different origin: (diabetic, alcoholic polyneuropathy)    pain in patients suffering from spine diseases (intercostal neuralgia, lumbar and cervical syndrome, cervico-brachial syndrome, radicular syndrome, pathological changes of the spine).The price and feedback on the effect of the drug on the treatment of these diseases indicate its high effectiveness when used in complex therapy.
There are contraindications for the use of the drug in the following cases:    intolerance of the components of the drug    cardiovascular failure    pregnancy and breastfeeding.
Taking vitamins, the patient can note the following side effects:    a variety of allergic reactions (itching of the skin, urticaria, anaphylactic shock, swelling)    tachycardia    acne    hyperhidrosis.
When using the drug solution injections are performed intramuscularly.If the symptoms of the disease are pronounced, injections are carried out for 5-7 days to 2 ml daily, after which the introduction of Combilipen is continued 2-3 times a week for another two weeks.With a mild form of the disease, injections are carried out 2-3 times a week for no more than 10 days. Treatment with Combilipen solution is carried out no more than two weeks, the dosage is adjusted by the attending physician.Instructions for the use of Combilipen Taps tablets are as follows: take the drug after meals, drink down with a small amount of water, do not chew. Adult patients take 1-3 tablets daily. The course of treatment is appointed by a specialist. Take high doses of the drug can not last longer than four weeks.
In case of an overdose, the symptoms of the side effect of the medicine may worsen. Perhaps the development of nausea, vomiting, dizziness, allergic reactions, tachycardia.If an overdose occurs, the patient should rinse the stomach, give him tablets of activated charcoal, prescribe symptomatic treatment.
If the injections of Combilipen or taking the drug orally combined with treatment with Levodopa, there is a decrease in the effect on the body of vitamin B6.Do not inject drugs with those substances that have oxidation-reduction effects, since they are incompatible with vitamin B1. It is mercury chloride, carbonate, iodide, acetate, tannic acid. In addition, the use of thiamine can not be combined with sodium phenobarbital, riboflavin, metabisulphite, benzylpenipple, dextrose. Thiamine breaks down very quickly, in contact with copper. Also, thiamine is inactivated when the pH exceeds 3.Vitamin B12 is not combined with heavy metal compounds.Storage conditions
Store the drug solution at a temperature not exceeding 8 degrees Celsius. The drug in tablets should be stored at a temperature not higher than 25 degrees Celsius. It is necessary to protect the medicine from children.Shelf life - 2 years.
During the period of treatment with the drug, multivitamins should not be used simultaneously, and B vitamins are present in the composition.Which is better: Milgamma or Combilipen?
Preparations Milgamma and Combilipen are analogues, they are made by different manufacturers. Effects on the human body, both drugs have a similar effect. However, the cost in the pharmacies of Milgamma is higher.Children
The composition of the drug is benzyl alcohol, so for the treatment of children Combilipen not applicable.With alcohol
If a person simultaneously takes medication with alcohol, the absorption of thiamine is sharply reduced. Therefore, discussing compatibility with alcohol, it should be noted that taking alcohol during treatment is highly undesirable.In pregnancy and lactation
The drug is not used during pregnancy and breastfeeding.
Reviews for Combilipen are mostly positive. Patients note its beneficial effect in the complex treatment of various neurological diseases. Leaving feedback on injections and reviews on Combilipen Tubs, people note its affordable price.Due to the presence of lidocaine in the composition, injections are less painful than the introduction of analogues of vitamin B containing vitamins. The doctors comments on the tablets and the solution of this drug show that it has a pronounced positive effect in the treatment of osteochondrosis. As adverse reactions in the reviews mentioned the appearance of a slight itch of the skin and urticaria.
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