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Cyproterone acetate, ethinyl estradiol, lactose monohydrate, sodium carboxymethyl starch, povidone, colloidal anhydrous silicon dioxide, colloidal aluminum oxide, magnesium stearate, succinic yellow, hypromellose, lactose monohydrate, macrogol, titanium dioxide, black oxide, black water.Tablets (placebo): lactose monohydrate, sodium carboxymethyl starch, povidone, colloidal anhydrous silica, colloidal aluminum oxide, magnesium stearate.
Tablets in a film cover, two types in the blister in cardboard packing No. 28:    Tablets of a round form, biconvex yellow-orange color in a film cover in the blister packing No. 21    Tablets (placebo) are round-shaped, biconvex white in blister pack No. 7.pharmachologic effectContraceptive with antiandrogenic action.
Chloe is a monophasic, low-dose, combined oral contraceptive with anti-androgenic activity. Its action is based on its active ingredients: cyproterone acetate with antiandrogenic effect and ethinyl estradiol (oral estrogen).Tsiproterona acetate - the mechanism of action is due to the ability to competitively bind with the receptors of natural androgens (androstenedione, dehydroepiandrosterone, testosterone), produced in the body of women in small quantities, mainly in the ovaries and adrenal glands. Due to its ability to block androgen receptors, cyproterone acetate disrupts hormone-receptor processes at the level of intracellular mechanisms, thereby reducing the manifestation of androgenization in women, which allows to treat diseases based on increased formation of androgens or high sensitivity to these hormones. In addition to the anti-androgen effect, cyproterone acetate has a histogenic effect that mimics the hormonal properties of the corpus luteum, inhibits the pituitary secretion of gonadotropic hormones and inhibits the process of ovulation, and this is due to its contraceptive effect.Ethinyl estradiol - enhances the effect (synergism) of cyproterone acetate on ovulation, maintains a high viscosity of mucus in the cervix, thereby making it difficult for sperm to enter the uterus, ensuring the reliability of contraceptive action.Chloe reduces the function of the sebaceous glands, whose products are actively involved in the occurrence of seborrhea and acne. Taking Chloe for 3-4 months leads to the disappearance of the rash that has appeared, increased oily skin and hair. While taking Chloe, the menstrual cycle becomes more regular, it reduces pain and bleeding intensity, which reduces the risk of developing iron deficiency anemia. Admission of Chloe after several months of treatment reduces the clinical symptoms of mild forms of hirsutism.Pharmacokinetics
Cyproterone acetate is rapidly and completely absorbed from the gastrointestinal tract. Cmax in the blood after taking 1 tablet Chloe inside comes in 1.5 hours. Bioavailability - 88%. High bond with albumin blood. Biotransformed in the liver in two phases by conjugation / hydroxylation with the formation of a 15b-hydroxyl metabolite. Excreted by the kidneys and through the intestines in the form of metabolites. T1 / 2 for the first phase is 0.8 hours and the second is 2.5 days.Ethinyl estradiol is completely and rapidly absorbed from the gastrointestinal tract. High degree of connection with blood albumin. The pharmacokinetics of ethinyl estradiol includes 2 phases. During the first phase of metabolism in the liver, ethinyl estradiol is extensively metabolized, which determines its bioavailability at the level of 45%. T1 / 2 of both phases on average is 20 hours. Excreted from the body through the intestines and kidneys in the form of metabolites.
For the purpose of contraception in women with clinical manifestations of androgenization    In the treatment of androgen-dependent diseases in women of reproductive age: pronounced forms of acne, accompanied by seborrhea, papular-pustular acne, nodular-cystic acne, androgenic alopecia, mild forms of hirsutism.
Joint reception with other hormonal drugs-contraceptives, venous thromboembolism, myocardial infarction, angina pectoris, stroke, uncontrolled arterial hypertension, cerebral vascular disease, prolonged immobilization, obesity, extensive injuries, diabetes, hormone-dependent tumors, tumors, tumors, tumor-bearing tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumor-like tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumors, tumor-like tumors, tumors, tumors, tumors, tumor-like tumors, tumors, tumors, tumors, tumor-like tumors, tumors-like tumors), tumors-like tumors, a tumor vagina of unknown etiology, pancreatitis, migraine with neurological focal symptoms, pregnancy, breastfeeding, congenital hyperbilirubinemia, lactase deficiency, lactose intolerance.Take care with patients with epilepsy, uterine myoma, depression, kidney disease, mastopathy, adolescence, tuberculosis, ulcerative colitis, multiple sclerosis, chorea, varicose veins, porphyria.
High sensitivity to the drug, migraine, headache, rash, urticaria, nausea, vomiting, diarrhea, abdominal pain, erythema nodosum, weight gain, engorgement and breast tenderness, acyclic bloody vaginal discharge, mood swings, decreased libido, thromboembolism, dizziness, cholecystitis, pancreatitis.
Chloe taken orally, 1 tablet per day, starting from the first day of the menstrual cycle. Do not chew the tablets, drink water or other liquid. Chloe must be taken every day at the same time. Reception duration - 21 days, then 7 days break.When you skip taking pills, you should take the drug for the next 12 hours. If the interval in the reception for more than 36 hours, the reliability of the contraceptive effect is not guaranteed and it is recommended to use non-hormonal methods of contraception. Treatment of androgenation symptoms requires many months of taking the drug and an additional 3-4 cycles after the disappearance of the disease.In the event of a relapse, re-treatment is possible. In the absence / weak efficacy of treatment of severe forms of seborrhea or acne, after 6 months of taking Chloe or 12 months of therapy of hirsutism and alopecia, cyproterone may be added.Overdose
Minor vaginal bleeding, nausea, vomiting.
When combined with Chloe with barbiturates, hydantoins, carbamazepine, primidone, rifampicin, oxcarbazepine, felbamate, griseofulvin and topiramate, the risk of breakthrough uterine bleeding increases, which may also lead to a decrease in contraceptive reliability.Simultaneous administration of Chloe with rifampicin, ampicillin, and tetracyclines dramatically reduces contraceptive reliability.Terms of sale
The prescription is not required to buy Chloe.Storage conditions
At a temperature of 5-20 ° C.Shelf life - 2 years.
Reviews of Chloe from patients vary widely, from positive to recommending not to take them because of the many side effects.    “... I drink Chloe for 6 months due to the high content of male hormones. There were problems with hair and skin. Im happy. Monthly steel on schedule, the skin is significantly cleared, there is practically no new rash, the pain in the lower abdomen during menstruation has stopped. I did not notice any side effects. Recommend".    “... Chloe saw year. The skin condition has improved, but problems have arisen - a strong appetite, has already gained 9 kg, and the breast has increased. But the worst thing is that I don’t want sex at all, constant quarrels with my husband on this basis, at times there were headaches and lethargy. Therefore, consider whether to take this drug. "'
|The purpose of the medication||Contraception|