ADRENALINE (Epinephrine, Adrenalin) 1 mg (1 ml), 5 ampoules

ADRENALINE (Epinephrine, Adrenalin) - is in a class of medications called alpha- and beta-adrenergic agonists (sympathomimetic agents). It works by relaxing the muscles in the airways and tightening the blood vessels. Epinephrine injection is used to treat life-threatening allergic reactions caused by insect bites or stings, foods, medications, latex, and other causes. It is usually injected as needed at the first sign of a serious allergic reaction. Use epinephrine injection exactly as directed do not inject it more often or inject more or less of it than prescribed by your doctor. You should inject epinephrine injection as soon as you suspect that you may be experiencing a serious allergic reaction. Signs of a serious allergic reaction include closing of the airways, wheezing, sneezing, hoarseness, hives, itching, swelling, skin redness, fast heartbeat, weak pulse, anxiety, confusion, stomach pain, losing control of urine or bowel movements, faintness, or loss of consciousness.

USES

• Often Used to Treat Cardiac Arrest
• Short-term Treatment of Anaphylaxis (Allergic Reactions)
• Infusions May Also be Used for Symptomatic Bradycardia
• Historically Been Used for the Treatment of Croup

GUARANTEE & EXPIRY DATE

Original from the Russian Moscow Endocrine Plant.

All packs are air tight sealed and expire up to 10.2027.

DESCRIPTION

Epinephrine, more commonly known as adrenaline, is a hormone secreted by the medulla of the adrenal glands.  Strong emotions such as fear or anger cause epinephrine to be released into the bloodstream, which causes an increase in heart rate, muscle strength, blood pressure, and sugar metabolism.  This reaction, known as the &ldquoFlight or Fight Response&rdquo prepares the body for strenuous activity.  In medicine epinephrine is used chiefly as a stimulant in cardiac arrest, as a vasoconstrictor in shock, and as a bronchodilator and antispasmodic in bronchial asthma.  Epinephrine is found in small amounts in the body and is essential for maintaining cardiovascular homeostasis because of its ability to divert blood to tissues under stress.



During cardiac arrest  the top priority is to maximize the amount of blood flow through the coronary artery.  Epinephrine, when injected into an intravenous fluid solution, will increase the coronary artery pressure thereby promoting increased coronary blood flow.  Increased doses of epinephrine quicken the response, but some studies have shown that brain and heart damage are some of the side effects.



Anaphylactic shock is caused whenever the heart is unable to pump enough blood throughout the body due to an allergic reaction, weakening of the heart muscle, or shrinking of the veins (vasodilation).  Injection of epinephrine into the blood stream will cause an increase of blood flow throughout the body.  The relief is only temporary due to the short half-life of adrenaline therefore, immediate hospitalization is required to ensure safety to the individual.



Individuals who are prone to asthma attacks have lung passages that are more susceptible to inflammation and swelling.  The swelling causes constriction of the muscles around the airway tubes and an increase in mucus.  The combination of these three leads to the shortness of breath, coughing, or wheezing common to those who suffer from asthma.  When inhaled in small doses, epinephrine causes short-term relief from the symptoms by widening the bronchial tubes allowing air to pass through.  Once again epinephrine is not the best cure, but a temporary relief when an asthma inhaler is not present.

PACKAGING

ADRENALINE comes in the form of ampoules for injection. 5 ampoules per pack.

Active ingredient: Epinephrine hydrochloride - 1 mg/ml, 1ml per ampoule.

Excipients: none.

DOSAGE

You must seek doctor's consultation to determine the optimal dose for your case.

Injected IM, IV or under skin. Depending on the clinical situation, a single dose for adults can range from 0.2 mg to 1 mg. For children - 0.1-0.5mg. Injection solution can be used as eye drops. Locally used to stop bleeding - using tampons moistened with a solution of epinephrine.

SIDE EFFECTS AND PRECAUTIONS

Cardiovascular system: angina, bradycardia or tachycardia, palpitations, increased or decreased blood pressure when used in high doses - ventricular arrhythmias rarely - arrhythmia, pain in the chest.

Nervous system disorders: headache, anxiety, tremor, dizziness, nervousness, fatigue, psychoneurotic disorders (psychomotor agitation, disorientation, impaired memory, aggressive or panic behavior, schizophrenia-like disorders, paranoia), sleep disturbances, muscle twitching.

Digestive system: nausea, vomiting.

Urinary system: rarely - difficult and painful urination (with prostatic hyperplasia).

Allergic reactions: angioedema, bronchospasm, skin rash, erythema multiforme.

Other: hypokalemia, increased sweating local reactions - pain or burning in the place of injection.

STORAGE

Store in dry place at room temperature. Do not exceed storage temperature higher than 25 degrees Celcius. Keep away from direct sunlight. Keep locked and away from children.

QUESTIONS?

Ask us any questions about ADRENALINE.